Strings 2, 3, and 4 are tuned like standard tuning, so start with soloing on that part of the neck. In fact, I did just that in the lead part on the 70s Rock Riff track. When you feel secure in that area of the neck, you can expand to the other strings.
Listen to the last chord in track 3 and then on track 4. You can hear beating on the last note of track 3, but not in the last chord on track 4. My note choice for the end of the lead part resulted in the beating partials.
The last note of the lead part lands on the G on the 4th string/7th fret. The 4th string tuning sounds about 2 cents higher than the open G notes in the rhythm guitar part. If I had played the open 3rd string G, there would have been no beating when played with the rhythm guitar.
This just goes to show that you need to be careful when soloing over the fine-tuned open G tuning. As it stands, the tuning error sounds no worse than equal temperament. (The guitar gets tuned to equal temperament when you tune using frets.)
Conversely, if I had played the final note on the 2nd string, the beating would have been much worse. Once again, always listen carefully when soloing in fine-tuned open G. Alternately, if you solo using a slide, you can lock in the notes of the solo with the tuning of the rhythm guitar part. Using the slide is another way you can get the rock star sound within open G tuning.